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Organized by the Institute of Experimental Physics,
University of Bialystok

under the auspices
of the Committee of Crystallography, Polish Academy of Sciences

This School is financially supported in part by
the International Union of Crystallography and the European Crystallographic Association

 
 

Chirality in bio and bioactive materials: measuring methods, feasibility (Jacek Grochowski , Poland)

Topics

  • Chirality of naturally originated large and small molecules
  • Glossary of terms describing stereoisomerism:
    - IUPAC terminology and conventions
  • Experimental methods for absolute structure determination:
    - Anomalous scattering with home and synchrotron X-ray sources
    - multiple beam X-ray diffraction
    - electron diffraction
    - feasibility study for light atoms containing molecules
    - example: absolute structure determination for molecule composed of O, N, C, H atoms
  • Assignment of absolute configuration:
    - circular dichroism spectroscopy
    - optical rotation
    - AFM
    - NMR spectroscopy
    - prediction from stereospecific synthesis
  • Naturally originated material - a real case:
    - poorly crystallising substances - antioxidants, odorants
    - epimeric equilibria - chiral drugs
    - instability of absolute configuration